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[Microadenomas and hypersecreting pituitary adenomas].

J L Vézina, J Hardy, M Yamashita

    Arquivos De Neuro-Psiquiatria
    |June 1, 1975
    PubMed
    Summary

    Radiographic analysis of the sella turcica reveals early signs of hypersecreting pituitary adenomas. Identifying specific changes aids in early microadenoma diagnosis and targeted surgery, preserving pituitary function.

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    Area of Science:

    • Endocrinology
    • Radiology
    • Neurosurgery

    Background:

    • Hypersecreting pituitary adenomas cause conditions like Cushing disease, acromegaly, and amenorrhea-galactorrhea.
    • Early detection of pituitary microadenomas is crucial to prevent irreversible damage to normal pituitary tissue.

    Purpose of the Study:

    • To report and discuss early radiographic changes of the sella turcica in hypersecreting pituitary adenomas.
    • To correlate radiographic findings with microadenoma localization for precise surgical planning.

    Main Methods:

    • Tomographic cuts of the sella turcica were used to identify specific radiographic changes.
    • Development of a 4-grade anatomo-radiologic classification for sella turcica alterations.

    Main Results:

    • Specific findings like a double contour of the sellar floor and antero-inferior wall bulging indicate microadenoma localization.
    • A 4-grade classification correlated with surgical cure rates: Grade 1 (>90%), Grade 2 (75%), Grade 3 (50%), Grade 4 (10%).

    Conclusions:

    • Early radiographic detection of sellar changes enables precise microadenoma localization.
    • Selective tumor excision in early stages preserves pituitary function and avoids hypopituitarism.
    • The proposed classification system is valuable for predicting surgical outcomes in pituitary adenoma treatment.

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