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Related Experiment Videos

Cognitive measures predict pathologic Alzheimer disease.

Matthew R Powell1, Glenn E Smith, David S Knopman

  • 1Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA.

Archives of Neurology
|June 14, 2006
PubMed
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Initial neuropsychologic test scores, specifically the Mayo Cognitive Factor Scales, can predict the presence of pathologic Alzheimer disease (AD). This finding aids in early diagnosis and understanding of AD progression.

Area of Science:

  • Neurology
  • Neuropsychology
  • Pathology

Background:

  • Clinicopathologic correlations for cognitive measures are limited.
  • Neuropsychologic testing infers neuropathologic processes.

Purpose of the Study:

  • Examine the utility of Mayo Cognitive Factor Scales (MCFS) for predicting pathologic Alzheimer disease (AD).
  • Assess MCFS at initial evaluations for predicting AD presence or absence.

Main Methods:

  • Longitudinal study of elderly patients followed until death.
  • Used age- and education-adjusted MCFS standard scores for classification accuracy.
  • Included 102 participants with neuropathologic examination at autopsy.

Main Results:

  • All MCFS scores significantly correlated with AD criteria.

Related Experiment Videos

  • Logistic regression showed high positive predictive value for pathologic AD.
  • Verbal Comprehension and Retention indices demonstrated moderate sensitivity and specificity.

    • Conclusions:

    • Neuropsychologic test scores at initial evaluations predict pathologic AD.
    • MCFS can be a valuable tool in AD diagnosis.