[Clinical experience of vecuronium bromide 10 mg preparation]

The neuromuscular blocking effects of vecuronium 10 mg preparation under enflurane anesthesia have been investigated in 22 patients having elective surgeries. The effect on cardiovascular system in man and laboratory examinations were also investigated. The results are as follows; 1. Onset time (time from end of injection until maximal blockade) after the dose of 0.08 or 0.1 mg.kg-1 of vecuronium bromide was about 2.6 minutes and 1.9 minutes, respectively. 2. Clinical duration of action (time from end of injection until 25% recovery of twitch) in the 0.1 mg.kg-1 group (about 50.1 minutes) was significantly longer than that in the 0.08 mg.kg-1 group (about 35.6 minutes). 3. Recovery time (time elapsing between 25 and 75% recovery of twitch) with neostigmine was 5.3 minutes (0.08 mg.kg-1) and 4.2 minutes (0.1 mg.kg-1). 4. Blood pressure was stable before and after the injection of vecuronium and no abnormal change related to the test drug was observed in the laboratory examinations. These data show that the efficacy and safety of the vecuronium 10 mg preparation are the same as those of the 4 mg preparation reported previously. In conclusion, it is considered that vecuronium 10 mg preparation is clinically useful because it is unnecessary to dissolve the drug frequently with injectable water.