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Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice
Published on: February 14, 2021
Baroreflex sensitivity measured by spectral and sequence analysis in cerebrovascular disease : methodological
Paul Johnson1, Angela Shore, John Potter
1Dept. of Medicine for the Elderly, Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK. paul.johnson@pms.ac.uk
Summary
Baroreflex sensitivity (BRS) measurement is reproducible in patients with cerebrovascular disease. Spectral and sequence analysis methods provide reliable BRS assessment for clinical studies.
Area of Science:
- Cardiovascular Physiology
- Neurology
- Biomedical Engineering
Background:
- Baroreflex sensitivity (BRS) is crucial in cardiovascular regulation and holds prognostic significance in cerebrovascular disease.
- Current BRS measurement techniques lack established reproducibility data in patients with cerebrovascular disease.
Purpose of the Study:
- To assess the reproducibility of spectral analysis and sequence analysis methods for measuring BRS in individuals with cerebrovascular disease.
- To determine the suitability of these BRS measurement techniques for longitudinal studies and clinical interventions.
Main Methods:
- Beat-to-beat blood pressure and ECG were recorded from 14 subjects with cerebrovascular disease on two separate occasions.
- Data were analyzed using spectral analysis (Fast Fourier Transform) and sequence analysis.
- Reproducibility was quantified using the coefficient of variation (CV) and reproducibility coefficient (RC).
Main Results:
- No significant differences in heart rate, blood pressure, or BRS were observed between assessment visits for either method.
- Spectral analysis yielded a CV of 22.2% and RC of 6.04 ms/mmHg.
- Sequence analysis yielded a CV of 26.3% and RC of 7.48 ms/mmHg, with high agreement between methods (r = 0.90).
Conclusions:
- Spectral and sequence analysis methods demonstrate good reproducibility for measuring BRS in patients with cerebrovascular disease.
- These validated techniques are appropriate for use in follow-up and intervention studies involving BRS in this population.
