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Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications
Published on: February 23, 2017
Preparation of hollow hydroxyapatite microspheres
Qing Wang1, Wenhai Huang, Deping Wang
1Institute of Bioengineering & Information Technology Materials, Tongji University, Shanghai, 200092, PR China.
Journal of Materials Science. Materials in Medicine
|June 14, 2006
Summary
Researchers created hollow hydroxyapatite (HA) microspheres for drug delivery. These porous, hollow HA microspheres were synthesized from glass particles and heat-treated for enhanced strength.
Area of Science:
- Biomaterials Science
- Materials Chemistry
- Drug Delivery Systems
Background:
- Hydroxyapatite (HA) is a key biomaterial for bone regeneration and drug delivery.
- Developing efficient methods for synthesizing HA-based drug delivery vehicles is crucial.
- Hollow microspheres offer advantages in drug loading and controlled release.
Purpose of the Study:
- To investigate the preparation of hollow hydroxyapatite (HA) microspheres.
- To evaluate their potential as drug-delivery vehicles.
- To optimize the synthesis process for HA microsphere formation.
Main Methods:
- Glass microspheres (10Li(2)O-15CaO-75B(2)O(3)) were prepared by flame spheroidization.
- Glass microspheres were reacted in potassium phosphate solution to form calcium phosphate (Ca-P) hollow microspheres.
- Heat treatment was applied to convert Ca-P to HA and enhance structural integrity.
Main Results:
- Porous, hollow microspheres with diameters of 106-125 microm were successfully synthesized.
- The Ca-P material was partially converted to hydroxyapatite (HA) via heat treatment at 600°C.
- Heat treatment also improved the mechanical strength of the hollow microspheres.
Conclusions:
- Hollow hydroxyapatite microspheres can be effectively prepared using a glass precursor route.
- The synthesized microspheres show promise as drug-delivery vehicles due to their structure and composition.
- Further studies are warranted to explore their drug loading and release characteristics.
