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Related Experiment Videos

Does obstructive sleep apnea increase hematocrit?

Jong Bae Choi1, José S Loredo, Daniel Norman

  • 1Department of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly, Kyunggi-do, South Korea.

Sleep & Breathing = Schlaf & Atmung
|June 14, 2006
PubMed
Summary

This study found that severe obstructive sleep apnea (OSA) is linked to higher hematocrit levels, even after accounting for other factors. However, OSA-related hypoxia typically does not cause clinical polycythemia.

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Area of Science:

  • Sleep Medicine
  • Hematology
  • Cardiovascular Physiology

Background:

  • Obstructive sleep apnea (OSA) is a common disorder characterized by repeated episodes of upper airway collapse during sleep.
  • Hematocrit levels, a measure of red blood cell volume, can be affected by hypoxia and inflammation.
  • The relationship between OSA severity, hypoxia, and hematocrit requires further clarification, considering potential confounding factors.

Purpose of the Study:

  • To investigate the association between obstructive sleep apnea severity and hematocrit levels.
  • To determine the influence of hypoxia and confounding variables on this relationship.

Main Methods:

  • A cohort of 263 subjects underwent polysomnography with oximetry.
  • Measurements included hematocrit, hemoglobin, BMI, blood pressure, and 24-h urine norepinephrine.

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  • Statistical analyses, including multiple linear regression, were used to assess relationships.

    • Main Results:

    • Patients with severe OSA (RDI >30) exhibited significantly higher hematocrit values compared to mild-to-moderate OSA or nonapneic controls.
    • Hematocrit levels correlated significantly with BMI, BP, urinary NE, RDI, and oxygen saturation parameters (percent time <90% and mean saturation).
    • Mean oxygen saturation, RDI, and percent time spent with oxygen saturation <90% were significant predictors of hematocrit, independent of confounders.

    Conclusions:

    • OSA severity is significantly associated with elevated hematocrit levels, even when controlling for confounding factors.
    • Despite nocturnal hypoxemia in OSA, clinical polycythemia is not a common outcome.