[Pathogenesis of the connective tissue in diabetes]

Non-enzymatic glycation and oxidative stress are main contributors in pathogenesis of the connective tissue changes in diabetes. Properties of separate parts in the connective tissue and particularly those of intercellular matrix may be impaired by both mechanisms. In addition, changes in microcirculation including endothelial dysfunction and also diabetic neuropathy further aggravate tissue impairment. Despite known pathogenic mechanisms in development of diabetic microangiopathy there are series of unresolved questions in the pathogenesis of diabetic skin disorders.