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Related Experiment Videos

Weil's disease with elevated plasma D-dimer.

K Ohnishi1, Y Kato, K Hayakawa

  • 1Department of Infectious Diseases, Tokyo Metropolitan Bokutoh General Hospital, Sumida City, Japan. infection@bokutoh-hp.metro.tokyo.jp

The Southeast Asian Journal of Tropical Medicine and Public Health
|June 15, 2006
PubMed
Summary

Weil's disease can cause elevated D-dimer levels during the acute phase. These levels normalize after treatment, suggesting fibrin formation and breakdown occur in acute Weil's disease.

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Area of Science:

  • Infectious Diseases
  • Hematology
  • Clinical Pathology

Background:

  • Weil's disease is a severe form of leptospirosis.
  • Early diagnosis and management are crucial for patient outcomes.
  • Understanding the pathophysiological mechanisms aids in treatment strategies.

Observation:

  • A case of Weil's disease presented with elevated plasma D-dimer levels in the acute phase.
  • Plasma D-dimer levels normalized during the convalescent phase following treatment.

Findings:

  • Elevated plasma D-dimer suggests activation of the coagulation and fibrinolytic systems.
  • The observed normalization indicates resolution of these processes post-treatment.

Implications:

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  • Plasma D-dimer may serve as a potential biomarker for disease activity in Weil's disease.
  • These findings suggest that significant fibrin formation and degradation occur during the acute phase.
  • Further research can explore the diagnostic and prognostic value of D-dimer in leptospirosis.