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Interleukin-2 receptor antagonist induction in modern immunosuppression regimens for renal transplant recipients

Flavio Vincenti1, Amado de Andrés, Thomas Becker

  • 1Transplant Service, University of California, San Francisco, San Francisco, USA. vincentif@surgery.ucsf.edu

Transplant International : Official Journal of the European Society for Organ Transplantation
|June 15, 2006
PubMed

Addition of interleukin-2 receptor antagonist (IL-2RA) induction to calcineurin inhibitor (CNI)-based regimens reduces biopsy-proven acute rejection by 30-40%. IL-2RA induction facilitates early withdrawal of steroids, and supports the safe use of reduced-exposure CNI or delayed CNI introduction. IL-2RAs and rabbit antithymocyte globulin (Thymoglobulin) show comparable efficacy in patients at standard or low immunologic risk, but the adverse event profiles of lymphocyte-depleting agents are less favorable. IL-2RAs, uniquely, provide effective immunosuppression with similar tolerability to placebo.

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