Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

FGF as a target-derived chemoattractant for developing motor axons genetically programmed by the LIM code.

Ryuichi Shirasaki1, Joseph W Lewcock, Karen Lettieri

  • 1Gene Expression Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.

Neuron
|June 15, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Circuit organization and transcriptomic heterogeneity of sympathetic circuits innervating cranial structures.

Cell reports·2026
Same author

Author Correction: Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution.

Nature communications·2026
Same author

Therapeutic targeting of neuroimmune mechanisms in neurodegeneration.

Nature reviews. Drug discovery·2026
Same author

Impaired nucleocytoplasmic transport in SOD1-mediated ALS.

Molecular neurodegeneration·2026
Same author

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism.

Nature communications·2026
Same author

Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer's disease.

Science translational medicine·2025
Same journal

Fast-conducting mechanonociceptors uniquely engage reflexive and affective pain circuitry to drive protective responses.

Neuron·2026
Same journal

Sparse component analysis: A method that uncovers separable computations within neural population activity.

Neuron·2026
Same journal

Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens.

Neuron·2026
Same journal

TGF-β1-induced endothelial transcytosis drives blood-brain barrier leakage during aging.

Neuron·2026
Same journal

Image space opens up for visual neuroscience.

Neuron·2026
Same journal

Septal GLP-1 receptors control alcohol taking and seeking.

Neuron·2026
See all related articles

Fibroblast growth factors (FGFs) guide specific motor neuron axons during development. This study identifies FGF receptor 1 (FGFR1) as crucial for this axon guidance, revealing a key mechanism in nervous system wiring.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Biology

Background:

  • LIM transcription factors are essential for guiding developing axons, but downstream receptors and ligands remain poorly understood.
  • The dermomyotome secretes a chemoattractant for medial-class spinal motor neuron axons (MMCm axons), crucial for axial muscle development.

Purpose of the Study:

  • To identify the specific ligands and receptors involved in dermomyotome-derived chemoattraction for MMCm axons.
  • To elucidate the role of fibroblast growth factor (FGF) signaling in motor axon guidance.
  • To understand how LIM codes regulate the expression of guidance receptors.

Main Methods:

  • In vitro chemoattraction assays using fibroblast growth factors (FGFs).
  • Analysis of Fibroblast Growth Factor Receptor 1 (FGFR1) expression patterns in motor neurons.

Related Experiment Videos

  • Conditional deletion of FGFR1 in mice to assess in vivo axon guidance.
  • Genetic reprogramming of motor neuron identity using the LIM factor Lhx3.

    • Main Results:

    • FGFs secreted by the dermomyotome selectively attract MMCm axons in vitro.
    • FGFR1 expression is specifically localized to MMCm neurons.
    • Conditional deletion of FGFR1 leads to significant motor axon guidance defects.
    • Lhx3-mediated reprogramming induces FGFR1 expression and an FGF-responsive state in other motor neuron populations.

    Conclusions:

    • FGF signaling plays a critical role in the specific guidance of MMCm axons.
    • FGFR1 acts as a key receptor mediating this FGF-dependent axon guidance.
    • LIM transcription factors, through Lhx3, regulate the expression of guidance receptors like FGFR1, thereby directing neural wiring.