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Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors
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Transcription factor FOXF1 regulates growth hormone variant gene expression

Jefferson P Lomenick1, Michael A Hubert, Stuart Handwerger

  • 1Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. jplome2@email.uky.edu

American Journal of Physiology. Endocrinology and Metabolism
|June 15, 2006
PubMed

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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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