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Fatigue in multiple sclerosis persists over time: a longitudinal study.

N Téllez1, J Río, M Tintoré

  • 12a planta EUI Unitat de Neuroimmunología, Clínica Hospital, Universitari Vall d'Hebron Ps, Vall d'Hebron 119-120, 08035, Barcelona, Spain. ntellez@vhebron.net

Journal of Neurology
|June 15, 2006
PubMed
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Fatigue in multiple sclerosis (MS) often persists long-term. Changes in depression levels, not disability, significantly impact fatigue severity over time in MS patients.

Area of Science:

  • Neurology
  • Clinical Psychology

Background:

  • Fatigue is a prevalent symptom in multiple sclerosis (MS).
  • Limited understanding exists regarding fatigue's long-term trajectory in MS.
  • Investigating factors influencing fatigue changes is crucial for patient management.

Purpose of the Study:

  • To analyze the longitudinal changes in fatigue severity among a large cohort of MS patients.
  • To determine the relationship between evolving disability and depression levels with fatigue severity.

Main Methods:

  • A cohort of 227 MS patients was assessed for fatigue using the Modified Fatigue Impact Scale (MFIS) and Fatigue Severity Scale (FSS).
  • Disability was measured by the Expanded Disability Status Scale (EDSS), and depression by the Beck Depression Inventory (BDI).
  • Assessments were conducted at baseline and after a one-year follow-up.

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Main Results:

  • A significant majority (86.8%) of initially fatigued MS patients remained fatigued at follow-up.
  • 25% of non-fatigued patients at baseline developed fatigue.
  • Increases in Beck Depression Inventory (BDI) scores strongly correlated with increased fatigue (MFIS: r = 0.49, p < 0.0001), predicting fatigue worsening.

Conclusions:

  • Fatigue is a persistent symptom in multiple sclerosis.
  • Changes in depression significantly influence fatigue severity in MS patients.
  • Disability progression and relapses did not show a significant relationship with changes in fatigue.