Related Experiment Video
Updated: Aug 7, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
[Treatment options for bipolar mania]
1Klinische Abteilung für Allgemeine Psychiatrie, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090 Wien, Osterreich. trawat.attarbaschi@meduniwien.ac.at
Abstract:
The diagnosis and treatment of bipolar mania are extremely challenging. Therapeutic intervention for mania has traditionally relied on the use of lithium or divalproex as a first-line treatment option. However, due to the limited therapeutic range of these agents, typical neuroleptics have often been used. Although these have demonstrated efficacy in mania, they are often associated with significant side effects, especially extrapyramidal symptoms. Thus, atypical antipsychotics are increasingly preferred in the treatment of bipolar mania. In this review, data from controlled studies for several of the atypical antipsychotics in the treatment of mania are surveyed and issues in the selection of an appropriate atypical agent are discussed.
Related Concept Videos
Mania and Antimanic Drugs: Overview
Bipolar Disorder
Psychosis: Goals of Pharmacotherapy
Drug Therapy
Antianxiety Medications
Antidepressant Drugs: MAOIs and Other Agents
Psychosis and Antipsychotic Drugs: Overview