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Related Experiment Videos

Hyperhidrosis in Parkinson's disease.

Pedro Schestatsky1, Josep Valls-Solé, João Arthur Ehlers

  • 1Unidade de EMG, Serviço de Neurologia, Hospital de Clínicas de Porto Alegre, Porto Alegre.

Movement Disorders : Official Journal of the Movement Disorder Society
|June 15, 2006
PubMed
Summary
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Parkinson's disease patients with hyperhidrosis showed reduced palm sweat gland activation. This suggests excessive sweating in some areas may compensate for decreased sympathetic function in extremities.

Area of Science:

  • Neurology
  • Dermatology
  • Autonomic Neuroscience

Background:

  • Parkinson's disease (PD) is a neurodegenerative disorder affecting motor function.
  • Autonomic dysfunction, including sudomotor abnormalities, is common in PD.
  • Symptomatic hyperhidrosis (excessive sweating) is a reported autonomic disturbance in PD patients.

Purpose of the Study:

  • To investigate the sudomotor skin response (SSR) in Parkinson's disease patients with and without symptomatic hyperhidrosis.
  • To compare SSR parameters between PD patients experiencing excessive sweating and those without.

Main Methods:

  • The study included 13 PD patients with hyperhidrosis and 37 PD patients without, matched for key clinical factors.
  • Sudomotor skin response (SSR) was recorded from the palm of the hand.

Related Experiment Videos

  • Electrical stimulation of the median nerve at the wrist was used to elicit the SSR.
  • Analysis focused on SSR onset latency, peak-to-peak amplitude, and waveform characteristics.

    • Main Results:

    • PD patients with hyperhidrosis exhibited a higher frequency of absent SSRs compared to those without.
    • The mean amplitude of SSRs was significantly lower in PD patients with hyperhidrosis.
    • A reduced number of SSRs with a predominantly negative component were observed in the hyperhidrosis group.

    Conclusions:

    • Excessive sweating in Parkinson's disease is associated with decreased sweat gland activation in the palms.
    • Axial hyperhidrosis in PD may represent a compensatory mechanism for diminished sympathetic function in peripheral extremities.