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A rare complement component C4 restriction fragment length polymorphism in two families with systemic lupus
R Goldstein1, J M Moulds, D P Sengar
1Division of Rheumatology, Ottawa General Hospital, University of Ottawa, ON, Canada.
The Journal of Rheumatology
|March 1, 1991
Abstract:
C4 null alleles with or without C4A,21-OHA gene deletions are associated with systemic lupus erythematosus (SLE) in various populations. We describe a new, rare C4 restriction fragment length polymorphism (RFLP), a Taq I 3.5 kb fragment, in 2 patients with SLE and their families. This RFLP is not associated with one particular major histocompatibility complex (MHC) haplotype and has not been reported in patients with SLE, patients with congenital adrenal insufficiency, or in healthy individuals.