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06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Body temperature and outcome after stroke thrombolysis
L Ernon1, M Schrooten, V Thijs
1Department of Neurology, University Hospital of Leuven, Leuven, Belgium.
Acta Neurologica Scandinavica
|June 16, 2006
Summary
Elevated body temperature after stroke and intravenous thrombolysis treatment is linked to poorer patient outcomes. Managing fever is crucial for improving recovery after stroke treatment.
Area of Science:
- Neurology
- Cardiovascular Medicine
- Critical Care Medicine
Background:
- Body temperature fluctuations after acute ischemic stroke can impact patient prognosis.
- Intravenous thrombolysis with tissue plasminogen activator (IV tPA) is a critical treatment for acute ischemic stroke.
- Understanding the role of temperature in stroke recovery is essential for optimizing treatment strategies.
Purpose of the Study:
- To investigate the association between baseline body temperature and post-stroke temperature changes with functional outcomes in patients receiving IV tPA.
- To determine if fever after stroke and thrombolysis treatment affects recovery.
- To analyze temperature parameters, including area under the curve relative to baseline (AUCBL) and relative to 37°C (AUC37), in relation to patient outcomes.
Main Methods:
- Retrospective analysis of 100 consecutive patients treated with IV tPA.
- Monitoring body temperature for the first 24 hours post-treatment.
- Calculating temperature evolution using AUCBL and AUC37.
- Correlating temperature parameters with functional outcomes, including favorable and unfavorable responses to tPA.
Main Results:
- Patients with unfavorable outcomes exhibited significantly higher temperature elevations (+1°C vs +0.6°C) and higher AUCBL values compared to those with favorable outcomes.
- Hyperthermia relative to baseline was more frequent in patients with unfavorable outcomes (82% vs 56%).
- After adjusting for baseline characteristics, hyperthermia relative to baseline was associated with reduced odds of a good outcome (OR 0.34, 95% CI 0.10-0.95).
Conclusions:
- Post-thrombolysis hyperthermia relative to baseline temperature in the 24 hours following IV tPA administration is significantly associated with unfavorable functional outcomes.
- These findings highlight the importance of temperature management in stroke patients undergoing thrombolysis.
- Further research may explore targeted fever reduction strategies to improve outcomes in this patient population.
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