Related Experiment Video
Updated: Aug 1, 2026
08:30
Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
Published on: August 14, 2017
Assessing bleeding in von Willebrand disease with bleeding score
Alberto Tosetto1, Giancarlo Castaman, Francesco Rodeghiero
1Hematology Department, S. Bortolo Hospital, 36100 Vicenza, Italy. tosetto@hemato.ven.it
Blood Reviews
|June 16, 2006
Summary
A bleeding score (BS) aids in diagnosing von Willebrand disease (VWD) by quantifying bleeding severity. This tool shows high specificity for type 1 VWD, offering a promising method for clinical analysis.
Area of Science:
- Hematology
- Clinical Diagnostics
Background:
- Quantifying bleeding severity in von Willebrand disease (VWD) is crucial for objective diagnosis.
- A bleeding score (BS) aggregates grades of bleeding severity across various hemorrhagic symptoms.
Purpose of the Study:
- To evaluate the utility of a bleeding score (BS) for quantifying bleeding severity in von Willebrand disease (VWD).
- To assess the diagnostic performance of the BS in identifying type 1 VWD.
Main Methods:
- A multicenter, retrospective study was conducted.
- The bleeding score (BS) was calculated by summing grades of bleeding severity for multiple hemorrhagic symptoms.
- Correlation with von Willebrand factor activity measurements, including PFA-100 closure time, was analyzed.
Main Results:
- In normal subjects, the BS is typically lower than 3.
- The BS demonstrated high specificity (99.1%) and satisfactory sensitivity (64.2%) for diagnosing type 1 VWD.
- The BS showed a strong relationship with all available measurements of von Willebrand factor activity.
Conclusions:
- The bleeding score (BS) is a promising clinical tool for analyzing bleeding in VWD.
- The BS can potentially assess the influence of other biological factors on VWD bleeding symptoms.
- Further validation is required before widespread clinical adoption of the BS for VWD diagnosis.
Related Concept Videos
01:19Assessing Blood pressure using a doppler ultrasound
To obtain accurate blood pressure measurements in clinical settings, especially when traditional methods are insufficient, healthcare professionals utilize the Doppler ultrasound technique. This method uses high-frequency sound waves to detect blood flow within the arteries, which is crucial for patients with conditions that complicate circulatory system assessment.
Pre-Procedural Guidelines for Doppler Ultrasound Blood Pressure Assessment:
Preparation of Equipment:
Pre-Procedural Guidelines for Doppler Ultrasound Blood Pressure Assessment:
Preparation of Equipment:
01:05Introduction to Hemostasis
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...
01:20Extrinsic and Intrinsic Pathways of Hemostasis
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
01:24Disorders of Hemostasis
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
01:28Esophageal Varices-II: Clinical Features and Management
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...
01:27Assessment of the Cardiovascular System III: Palpation
Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above the...
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above the...