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Cholinergic modulation of trace conditioning trained in serial compound: A developmental analysis.

Pamela S Hunt1, Robert C Barnet, Meghan E Shea

  • 1Department of Psychology, College of William and Mary, PO Box 8795, Williamsburg, VA 23187-8795, USA. pshunt@wm.edu

Neurobiology of Learning and Memory
|June 16, 2006
PubMed
Summary

Serial compound conditioning enables trace fear conditioning in young rats by enhancing cholinergic activity. This suggests developmental maturation of neural pathways is key for trace conditioning emergence.

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Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Behavioral Neuroscience

Background:

  • Trace fear conditioning is typically absent in young rats.
  • Cholinergic systems are crucial for learning and memory.

Purpose of the Study:

  • To investigate if serial compound conditioning can facilitate trace fear conditioning in young rats.
  • To explore the role of cholinergic mechanisms in trace and serial conditioning in developing rats.

Main Methods:

  • Four experiments used Sprague-Dawley rats (18- and 25-day-old) in a fear conditioning paradigm.
  • Standard trace (CS1-->trace interval-->US) and serial (CS1-->CS2-->US) conditioning were compared.
  • The muscarinic receptor antagonist scopolamine was administered pre-training to assess cholinergic involvement.

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Main Results:

  • Eighteen-day-old rats successfully exhibited trace conditioning when the interval was filled (serial conditioning).
  • Scopolamine dose-dependently reduced responding to the trace CS1 in both training groups.
  • Responding to CS2 was not affected by scopolamine, indicating specific effects on trace learning.

Conclusions:

  • Serial compound conditioning promotes trace conditioning in young rats, potentially by enhancing cholinergic activity.
  • Cholinergic systems are functional in young rats but may require specific training paradigms for activation.
  • These findings shed light on the ontogenetic emergence of trace conditioning and the role of neural pathway maturation.