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Growth in post-viral chronic lung disease
Mariana del Pino1, Gabriela Bauer, Hebe González Pena
1Growth and Development, Garrahan Hospital, Combate de los Pozos 1881 (1245), Buenos Aires, Argentina. mdelpino@garrahan.gov.ar
European Journal of Pediatrics
|June 16, 2006
Summary
Children with post-viral chronic lung disease (PVCLD) show varied growth patterns, but most achieve satisfactory outcomes. Chronic hypercapnia is linked to slower growth in these pediatric patients.
Area of Science:
- Pediatric Pulmonology
- Respiratory Medicine
- Child Health
Background:
- Adenovirus infections can lead to chronic lung disease (CLD) in infants.
- Post-viral chronic lung disease (PVCLD) impacts children's long-term respiratory health.
- Understanding growth patterns in PVCLD is crucial for managing chronic respiratory conditions in children.
Purpose of the Study:
- To describe height and weight growth in children diagnosed with PVCLD.
- To investigate associations between growth and factors like mechanical ventilation, chronic hypercapnia, home oxygen therapy, and steroid use.
- To analyze growth trajectories and identify risk factors for impaired growth in pediatric PVCLD.
Main Methods:
- A cohort of 99 patients with PVCLD and over one year of follow-up was studied.
- Median follow-up duration was 3.10 years, with a median age at disease onset of 0.50 years.
- Growth patterns were categorized, and associations with clinical variables were statistically analyzed.
Main Results:
- Growth in height was categorized into normal (Type A, 48 children) and slow growth (Type B, 50 children), with most experiencing catch-up growth.
- Chronic hypercapnia was identified as a significant risk factor for slow growth (OR: 5.03; 95% CI: 1.83/13.83).
- Higher weight-for-height ratios during slow growth correlated with greater subsequent height gains (r=0.46).
Conclusions:
- Growth in children with PVCLD is heterogeneous but generally satisfactory for most individuals.
- Chronic hypercapnia is a key factor associated with slower growth trajectories in pediatric PVCLD.
- These findings highlight the importance of monitoring and managing hypercapnia to optimize growth in children with post-viral chronic lung disease.
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