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Related Experiment Videos

[Painful tic convulsif and Botulinum toxin].

M E Boscá-Blasco1, J A Burguera-Hernández, S Roig-Morata

  • 1Servicio de Neurología, Hospital Universitari La Fe, 46009 Valencia, España. bosca_mar@gva.es

Revista De Neurologia
|June 16, 2006
PubMed
Summary

Botulinum toxin effectively treated painful tic convulsif, a rare disorder combining trigeminal neuralgia (TN) and hemifacial spasm (HFS). This suggests a shared cause and a central mechanism of action for the toxin in managing these hyperactive cranial nerve conditions.

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Area of Science:

  • Neurology
  • Neurosurgery
  • Pharmacology

Background:

  • Painful tic convulsif, characterized by trigeminal neuralgia (TN) and ipsilateral hemifacial spasm (HFS), is a rare disorder.
  • Both TN and HFS are common examples of hyperactive cranial rhizopathy.
  • Vascular compression of cranial nerves at the brain stem's nerve root entry/exit zone often causes these conditions, leading to ephaptic transmission.

Observation:

  • This study reports on four patients with combined TN and HFS treated with botulinum toxin.
  • Three patients had ipsilateral TN and HFS, with one experiencing bilateral HFS.
  • One patient presented with contralateral TN to the HFS.

Findings:

  • All four patients showed improvement in both HFS and TN following botulinum toxin treatment.

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  • The study suggests a common etiology for TN and HFS, possibly central neuronal hyperactivity or multi-cranial nerve compression.
  • Botulinum toxin's efficacy in both conditions supports a central mechanism of action, potentially modulating brainstem neuronal hyperactivity.

    • Implications:

    • Botulinum toxin may offer a therapeutic option for patients with combined TN and HFS.
    • Further research into the central effects of botulinum toxin for neurological disorders is warranted.
    • Understanding the shared etiology of TN and HFS could lead to more targeted treatments.