Related Experiment Video
Updated: Aug 7, 2026
06:12
LPS and ATP-induced Death of PMA-differentiated THP-1 Macrophages and its Validation
Published on: May 3, 2024
[Apoptosis and programmed cell death. Host parasite relationship new paradigm]
1L'EA 37-32, Praticien, Virulence et résistance des Plasmodium, Faculté de Médecine, Université Claude Bernard, Lyon, France. picot@sante.univ-lyon1.fr
Medecine Tropicale : Revue Du Corps De Sante Colonial
|June 17, 2006
Summary
Understanding programmed cell death in host-parasite interactions is key. Deciphering how parasites influence host cell death could lead to new disease control strategies.
Area of Science:
- Explores the intricate relationship between host and parasite at the cellular level.
- Focuses on the biological processes of apoptosis and programmed cell death.
Context:
- Investigates the dual role of parasite-induced cell death: virulence versus transmissibility.
- Examines the impact of individual parasite death on overall population survival.
Purpose:
- To understand the mechanisms by which parasites manipulate host cell death.
- To explore the implications of programmed cell death in host-parasite dynamics.
Summary:
- Growing data suggests programmed cell death is a critical factor in host-parasite relationships.
- Parasites may induce or inhibit host cell death, influencing both virulence and transmission.
- These processes are mediated by highly regulated, specific mechanisms.
Impact:
- Deciphering these mechanisms offers potential new avenues for controlling parasitic diseases.
- Understanding parasite-mediated apoptosis can revolutionize therapeutic strategies.
Related Concept Videos
01:30Overview of Cell Death
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...
01:30Apoptosis
Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size reduction of the tissue.
01:22Microbial Interactions: Parasitism
Parasitism is a form of microbial interaction in which parasitic microbes exploit a host organism for nutrients and shelter, often at the host's expense. Unlike mutualistic relationships, where both organisms benefit, parasitism benefits only the parasite and harms the host.Classification of ParasitesMicrobial parasites are broadly classified based on their location relative to the host.Ectoparasites remain on the host’s surface, such as the skin or outer tissues, drawing nutrients...
01:22Cellular Injury V: Apoptosis and Autophagy
Cells respond to damage and stress through highly coordinated processes that decide whether they survive or undergo controlled self-destruction. Two major pathways involved in this regulation are apoptosis, a type of programmed cell death, and autophagy, a survival mechanism that helps cells adapt to adverse conditions.ApoptosisApoptosis removes aged or injured cells to maintain tissue balance. During this process, the cell shrinks, chromatin condenses and fragments, and membrane-bound...
01:17Phagocytosis of Apoptotic Cells
Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or immature dendritic cells. Non-professional phagocytes such as epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes.
Normal cells contain receptors that prevent them from being recognized by phagocytes.
Normal cells contain receptors that prevent them from being recognized by phagocytes.
01:18Autophagic Cell Death
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and pro-apoptotic...
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and pro-apoptotic...