Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The hedgehog pathway and neurological disorders.

Tammy Dellovade1, Justyna T Romer, Tom Curran

  • 1Curis, Inc., Cambridge, Massachusetts 02138, USA. tdellovade@curis.com

Annual Review of Neuroscience
|June 17, 2006
PubMed
Summary

The hedgehog pathway regulates development and adult tissue function. This review explores its role in neural diseases and potential therapeutic applications using small molecules.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An induced pluripotent stem cell-based chemical genetic approach for studying spinal muscular atrophy.

Frontiers in neuroscience·2026
Same author

Liver Steatosis in Induced Hepatocytes From Carriers of Spinal Muscular Atrophy.

Muscle & nerve·2026
Same author

An induced pluripotent stem cell-based chemical genetic approach for studying spinal muscular atrophy.

bioRxiv : the preprint server for biology·2025
Same author

Development of a robust, physiologically relevant neuronal tau aggregation assay for tau-related drug discovery.

The Journal of biological chemistry·2025
Same author

Activated GDF11/8 subforms predict cardiovascular events and mortality in humans.

Nature communications·2025
Same author

Anti-pyroglutamate-3 Aβ immunotherapy engages microglia and inhibits amyloid accumulation in transgenic mouse models of Aβ amyloidosis.

Acta neuropathologica·2025

Area of Science:

  • Developmental Biology
  • Neuroscience
  • Molecular Biology

Background:

  • The hedgehog pathway is crucial for embryonic development, particularly nervous system formation.
  • It also plays a role in adult tissues, regulating cell proliferation and growth factors.
  • Its function is vital in adult neural stem and progenitor cell behavior.

Purpose of the Study:

  • To review the connection between hedgehog signaling and neural diseases.
  • To discuss the role of hedgehog pathway in neurodegenerative disorders and brain tumors like medulloblastoma.
  • To highlight the therapeutic potential of small molecule modulators.

Main Methods:

  • Literature review of studies on hedgehog signaling in neural development and disease.
  • Analysis of research on neural stem and progenitor cell regulation.
  • Examination of small molecule agonists and antagonists for hedgehog pathway modulation.

Main Results:

  • Hedgehog pathway mutations are linked to severe nervous system defects.
  • The pathway regulates adult neural stem cells and progenitor cells.
  • It is implicated in neurodegenerative diseases and brain tumors, especially medulloblastoma.

Conclusions:

  • The hedgehog pathway is a significant target for understanding and treating neural diseases.
  • Small molecule agonists and antagonists offer promising therapeutic avenues.
  • Further research into hedgehog signaling could lead to novel treatments for neurological conditions.

Related Experiment Videos