Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Phytoestrogens and cardiovascular disease.

Aedín Cassidy1, Lee Hooper

  • 1School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK. a.cassidy@uea.ac.uk

The Journal of the British Menopause Society
|June 17, 2006
PubMed
Summary

Soy isoflavones in soy protein isolate may reduce LDL cholesterol, but effects on other lipids are unclear. The active components in soy remain unidentified, necessitating further research on whole soy foods for cardiovascular outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plant-Based Diets, Ultra-Processed Foods, and Risks of Mortality and Major Chronic Diseases: A Prospective Cohort Study.

The Lancet regional health. Europe·2026
Same author

Prevalence of low-intake dehydration in hospitalised older adults: systematic review and meta-analysis.

BMJ public health·2026
Same author

Dietary vitamin K intakes, chronic obstructive pulmonary disease, adult asthma, and lung function: a prospective cohort study in the UK Biobank.

The American journal of clinical nutrition·2026
Same author

Associations between source-specific nitrate and nitrite intakes and metabolic dysfunction-associated steatotic liver disease in two prospective cohorts.

Clinical nutrition (Edinburgh, Scotland)·2026
Same author

The Prime Diet Quality Score (PDQS), chronic disease and cause-specific mortality in UK Biobank: a prospective study.

European journal of nutrition·2026
Same author

[The European Society for Clinical Nutrition and Metabolism (ESPEN) Guideline on Clinical Nutrition and Hydration in Geriatrics].

Revista espanola de geriatria y gerontologia·2026

Area of Science:

  • Nutritional Science
  • Cardiovascular Health
  • Phytoestrogen Research

Background:

  • Isoflavones, a major class of phytoestrogens found in soybeans, have been extensively studied for their health effects.
  • Previous systematic reviews suggest soy protein isolate (ISP) with isoflavones reduces LDL cholesterol, but evidence for other lipids is inconsistent.

Purpose of the Study:

  • To review the effects of soy isoflavones and soy protein on lipid levels and other cardiovascular risk markers.
  • To clarify the active components within soy responsible for observed health effects.
  • To identify areas for future research on whole soy foods and cardiovascular outcomes.

Main Methods:

  • Systematic review of existing literature on soy isoflavones and cardiovascular biomarkers.
  • Analysis of data from six systematic reviews assessing soy isoflavones' impact on lipid profiles.

Related Experiment Videos

  • Evaluation of evidence regarding effects on blood pressure, endothelial function, and homocysteine.

    • Main Results:

    • Soy protein isolate (ISP) containing isoflavones significantly reduces low-density lipoprotein (LDL) cholesterol by approximately 0.15 mmol/L.
    • No significant effects were observed on triglyceride or high-density lipoprotein (HDL) cholesterol levels.
    • Purified isoflavones or soy protein lacking isoflavones did not show statistically significant lipid-lowering effects.
    • Potential benefits on endothelial function in postmenopausal women and homocysteine concentrations were noted.
    • Adverse effects were minimal at physiological doses, with some gastrointestinal and menstrual complaints reported with supplements.

    Conclusions:

    • Soy protein isolate with isoflavones demonstrates a modest LDL cholesterol-lowering effect.
    • The specific active components in soy (isoflavones, protein matrix, or other compounds) require further elucidation.
    • Robust studies on whole soy foods and their impact on cardiovascular events are essential.