Primary synovial sarcoma of the lung
Carlos Zamarrón1, Ihab Abdulkader, Uxio Calvo Alvarez
1Division of Respiratory Medicine, Hospital Clínico Universitario, Santiago, Spain.
Internal Medicine (Tokyo, Japan)
|June 17, 2006
Summary
A rare synovial sarcoma presented as a large pulmonary tumor in a 45-year-old woman. Genetic analysis confirmed the diagnosis by detecting SYT/SSX fusion transcripts.
Area of Science:
- Pulmonology
- Oncology
- Molecular Pathology
Background:
- Pulmonary tumors can present with diverse histopathological features.
- Accurate diagnosis is crucial for appropriate patient management and treatment strategies.
Observation:
- A 45-year-old female presented with chest pain and a distinct oval mass on chest radiography.
- Surgical resection revealed a large, pale-yellow, soft tumor measuring 13 x 12 cm.
Findings:
- Histological examination showed round, oval, and spindle-shaped cells with specific nuclear and cytoplasmic features.
- Immunohistochemistry revealed positivity for vimentin, CD 99, BCL-2, and EMA.
- Reverse transcriptase-polymerase chain reaction (RT-PCR) confirmed the presence of SYT/SSX-2 fusion transcripts, indicative of synovial sarcoma.
Implications:
- This case highlights the importance of comprehensive diagnostic methods, including molecular analysis, for rare pulmonary neoplasms.
- Definitive diagnosis of synovial sarcoma aids in guiding targeted therapy and prognostic assessment.
- Understanding the molecular basis of such tumors can inform future research and therapeutic development.
Related Concept Videos
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:13Pleura of the Lungs
The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
01:28Pulmonary Tuberculosis II
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
01:31Pulmonary Tuberculosis III
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
01:17Gross Anatomy of the Lungs
The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...