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Updated: Aug 7, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

Magnetic resonance imaging of delayed enhancement in hypertrophic cardiomyopathy: relationship with left ventricular

Rafaela Soler1, Esther Rodríguez, Lorenzo Monserrat

  • 1Department of Radiology, Complejo Hospitalario Universitario Juan Canalejo, La Coruña, Spain. rafaelasoler@telefonica.net

Journal of Computer Assisted Tomography
|June 17, 2006
PubMed

Insights

Delayed myocardial enhancement is common in hypertrophic cardiomyopathy (HCM), often linked to perfusion defects and reduced contractile function. These findings suggest potential roles in risk stratification for HCM patients.

Area of Science:

  • Cardiovascular Imaging
  • Cardiac MRI
  • Cardiology

Background:

  • Hypertrophic cardiomyopathy (HCM) is a primary cause of sudden cardiac death in young adults.
  • Cardiac MRI (CMR) is crucial for diagnosing and characterizing HCM.
  • Understanding the relationship between different CMR findings is essential for patient management.

Purpose of the Study:

  • To investigate the associations between myocardial delayed enhancement (MDE), first-pass perfusion (FPP), and contractile function in HCM patients.
  • To determine the prevalence and distribution of MDE in HCM.
  • To explore the clinical significance of these CMR parameters.

Main Methods:

  • Prospective CMR examination of 53 HCM patients using a 1.5-T MR unit.
  • Assessment of global left ventricular function, wall thickness, and mass.
  • Myocardial tissue tagging for contractile function evaluation.
  • T1-weighted sequences for FPP and MDE assessment.

Main Results:

  • MDE was observed in 56.6% of patients, predominantly in hypertrophic segments, but also in normal-thickness segments.
  • FPP defects at rest occurred in 30.1% of patients, correlating with reduced stroke volume and cardiac output.
  • Hypokinetic segments were significantly thicker and associated with MDE.

Conclusions:

  • MDE is prevalent in HCM, occurring in both hypertrophic and normal-thickness segments.
  • Resting FPP defects and impaired contractile function are associated with MDE.
  • Further research is needed to establish the role of MDE, FPP, and myocardial tagging in HCM risk stratification.
Abstract

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