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DDT and pyrethroids--ecotoxicological considerations.

P Eriksson1

  • 1Department of Zoophysiology, Uppsala University, Sweden.

Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology
|January 1, 1991
PubMed
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Early exposure to DDT and certain pesticides permanently alters brain development and behavior in neonatal mice by affecting muscarinic cholinergic receptors (MAChR). These changes persist into adulthood, highlighting developmental neurotoxicity risks.

Area of Science:

  • Neuroscience
  • Environmental Toxicology
  • Developmental Biology

Background:

  • Pesticides like DDT, bioallethrin, and deltamethrin are widely used, raising concerns about their impact on developing nervous systems.
  • Muscarinic cholinergic receptors (MAChR) play a critical role in brain development and function.

Purpose of the Study:

  • To investigate the effects of early-life exposure to DDT, its metabolite DDOH-PA, bioallethrin, and deltamethrin on MAChR in neonatal mouse brains.
  • To determine if these early exposures lead to lasting changes in cholinergic systems and behavior in adulthood.

Main Methods:

  • Neonatal mice (10-day-old) were administered DDT, DDOH-PA, bioallethrin, and deltamethrin during a critical period of brain growth.
  • Subsequent assessments evaluated effects on muscarinic cholinergic receptors and long-term behavioral and cholinergic variables in adulthood.

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Main Results:

  • Exposure to DDT, DDOH-PA, bioallethrin, and deltamethrin affected muscarinic cholinergic receptors (MAChR) in the neonatal mouse brain.
  • Early-life exposure resulted in permanent alterations in cholinergic and behavioral variables observed in adult mice.

Conclusions:

  • Neonatal exposure to specific pesticides can disrupt MAChR function during critical developmental windows.
  • These disruptions can lead to persistent neurodevelopmental and behavioral deficits, underscoring the potential for long-term neurotoxicity from early environmental exposures.