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Updated: Aug 7, 2026

Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs
Published on: July 23, 2016
Qualitative pharmacokinetic modeling of drugs
Richard Boyce1, Carol Collins, John Horn
1Department of Biomedical and Health Informatics, University of Washington, USA.
Abstract:
We hypothesize that a representation of drug-drug interactions (DDIs) based on physiologic, pharmacokinetic (PK) and pharmacodynamic (PD) mechanisms will provide more accurate and useful information to clinicians than current approaches that simply tabulate and index pairwise interactions of drugs. This paper explores the strengths, weaknesses, and difficulties of modeling drug mechanisms and reports on our initial work designing and implementing a drug KB based on qualitative pharmacokinetic mechanisms.
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