Related Experiment Video
Updated: Aug 7, 2026
11:18
Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research
Published on: January 22, 2011
Providing PDA-based clinical trial listings to oncologists
Valerie Monaco1, Samuel A Jacobs, Aab M Arnold
1University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.
AMIA ... Annual Symposium Proceedings. AMIA Symposium
|June 17, 2006
Summary
Low enrollment in adult cancer clinical trials is a problem. A new digital tool helps oncologists find trials for patients, aiming to improve participation and outcomes in cancer research.
Area of Science:
- Oncology
- Clinical Trials
- Health Informatics
Background:
- Sub-optimal accrual rates in adult oncology clinical trials are a persistent challenge.
- Identifying suitable clinical trials for patients represents a significant barrier to trial participation.
Purpose of the Study:
- To address the barrier of identifying clinical trials for patients.
- To introduce a clinical trial listing tool for oncologists' personal digital assistants (PDAs).
Main Methods:
- Development of a clinical trial listing accessible via PDAs.
- Gathering preliminary feedback from an initial group of physicians using the resource.
Main Results:
- The study gathered preliminary feedback on the PDA-based clinical trial listing.
- Physicians' perspectives on the benefits and potential enhancements were collected.
Conclusions:
- The PDA-based clinical trial listing shows promise in addressing accrual barriers.
- Further enhancements are planned based on physician feedback to optimize the tool's utility.
Related Concept Videos
01:11Clinical Trials: Overview
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
01:16Clinical Trials
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
02:50Combination Therapies and Personalized Medicine
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
01:28Preclinical Development: Overview
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
01:12Hazard Ratio
The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial evaluating a...
For example, in a clinical trial evaluating a...