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Emergence of multidrug-resistant Salmonella enterica serotype Newport in Minnesota

Vanessa C Lopes1, Stephanie D Wedel, Jeffrey B Bender

  • 1Department of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul 55108, USA.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|June 17, 2006
PubMed

Insights

Multidrug-resistant Salmonella Newport infections are increasing in Minnesota. Analysis suggests a single clone may be responsible for the rise in resistant Salmonella enterica serotype Newport cases in both animals and humans.

Area of Science:

  • Microbiology
  • Epidemiology
  • Public Health

Background:

  • Salmonella enterica serotype Newport (S. Newport) is a significant cause of foodborne illness.
  • Increasing antimicrobial resistance in bacterial pathogens poses a global health threat.

Purpose of the Study:

  • To investigate the concurrent increase in S. Newport isolates and multidrug resistance (MDR) in Minnesota.
  • To determine the genetic relatedness and resistance profiles of MDR S. Newport isolates.

Main Methods:

  • Antimicrobial susceptibility testing was performed on S. Newport isolates from human and animal sources.
  • Pulsed-field gel electrophoresis (PFGE) was used to analyze the genetic diversity of the isolates.
  • Class 1 integrons were identified in resistant isolates.

Main Results:

  • A concurrent rise in the number of S. Newport isolates and MDR rates was observed in Minnesota.
  • PFGE analysis revealed heterogeneity among isolates but identified a major cluster.
  • This cluster predominantly contained MDR isolates with a specific resistance pattern and class 1 integrons.

Conclusions:

  • The findings suggest a clonal expansion of a specific MDR S. Newport strain.
  • This clonal strain appears to be circulating in both animal and human populations in Minnesota.
  • Public health surveillance and control measures are crucial to address the spread of MDR S. Newport.

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