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Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
Published on: September 15, 2023
[Off-pump coronary artery bypass in high-risk patients]
T Hanada1, T Higami, K Kanetsuki
1Department of Cardiovascular and General Surgery, School of Medicine, Shimane University, Izumo, Japan.
Insights
Off-pump coronary artery bypass (OPCAB) surgery showed favorable early outcomes in high-risk patients. This technique using arterial grafts is particularly beneficial for those with cerebrovascular diseases.
Area of Science:
- Cardiovascular Surgery
- Minimally Invasive Cardiac Procedures
- Vascular Grafting
Context:
- Off-pump coronary artery bypass (OPCAB) is a surgical technique to revascularize the heart without using cardiopulmonary bypass.
- Evaluating early outcomes of OPCAB is crucial for establishing its efficacy, especially in high-risk patient populations.
- The aortic no-touch technique with arterial grafts offers a potential advantage in specific patient groups.
Purpose:
- To evaluate the early operative results of off-pump coronary artery bypass (OPCAB) in a cohort of 110 patients.
- To compare outcomes between high-risk (H group) and low-risk (L group) patients undergoing OPCAB.
- To assess the utility of OPCAB using in situ arterial grafts, particularly in patients with cerebrovascular diseases.
Summary:
- A study of 110 patients undergoing OPCAB found comparable graft numbers and complete revascularization rates between high-risk and low-risk groups.
- All patients achieved coronary revascularization using the aortic no-touch technique exclusively with arterial grafts.
- The high-risk group experienced a low in-hospital mortality (1.5%) and no cerebral infarction, with complication rates similar to the low-risk group.
Impact:
- Off-pump coronary artery bypass (OPCAB) demonstrates good early results for high-risk patients.
- The use of in situ arterial grafts in OPCAB is highly effective, especially for patients with cerebrovascular conditions.
- This study supports OPCAB as a viable and safe revascularization strategy in complex cardiac surgical cases.
Abstract:
In this study, 110 consecutive patients who had undergone off-pump coronary artery bypass (OPCAB) in the past 2 years were evaluated for early results of OPCAB. Patients were classified as a high-risk group (H group: 68 patients consisting of 46 men and 22 women) and a low-risk group (L group: 42 patients consisting of 31 men and 11 women), respectively, and were evaluated for the early operative results. No differences were noted between the H and L groups in the mean number of bypass grafts (2.9 +/- 0.9 in the H group, 2.9 +/- 0.9 in the L group), the rates of complete revascularization (85% in the H group, 93% in the L group), those of various graft materials bypassed, or those of sequential bypass. In all patients, we were able to undergo coronary revascularization by the aortic no-touch technique using arterial grafts exclusively. In the H group, 1 patient (1.5%) died in hospital, but no patients developed cerebral infarction postoperatively, and the frequency of complications was similar to that in the L group. The results of OPCAB for high-risk patients were good, and it was suggested that OPCAB using in situ arterial grafts was very useful particularly in patients with cerebrovascular diseases.
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