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[Constituents in the alkaloid fraction of Kushen decoction]
1School of Chinese Pharmacology, Beijing University of Traditional Chinese Medicine, Beijing 100102, China. liubinyn67@163.com
Objective:
To study the chemical constituents of the alkaloid fraction of Kushen decoction.
Method:
Constituents were isolated by different kinds of column chromatography and their structures were elucidated with spectral methods.
Result:
Eight compounds were isolated and identified as matrine (I), sophoridine (II), sophocarpine (III), sophoramine (IV), oxymatrine (V), oxysophocarpine (VI), aloperine (VII) and sparteine (VIII).
Conclusion:
All these compounds were isolated from Kushen decoction for the first time. Aloperine was found firstly in Sophora flavescens, or Scutellaria baicalensis, or Rehmannia glutinosa which constituted Kushen decoction.
