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Fatigue in ankylosing spondylitis.

B Missaoui1, M Revel

  • 1Service de Rééducation et de Réadaptation de l'Appareil Locomoteur et des Pathologies du Rachis, Faculté de Médecine, Université René-Descartes, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, France. elisabeth.vinard@cch.aphp.fr

Annales De Readaptation Et De Medecine Physique : Revue Scientifique De La Societe Francaise De Reeducation Fonctionnelle De Readaptation Et De Medecine Physique
|June 20, 2006
PubMed
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Fatigue is common in ankylosing spondylitis (AS) and impacts quality of life. While current assessment tools are limited, anti-TNF therapy and regular exercise show promise for managing AS fatigue.

Area of Science:

  • Rheumatology
  • Clinical Medicine
  • Patient Outcomes

Background:

  • Fatigue is a prevalent and debilitating symptom in ankylosing spondylitis (AS).
  • Understanding fatigue's impact and management is crucial for improving patient quality of life.

Purpose of the Study:

  • To conduct a literature review on fatigue in ankylosing spondylitis.
  • To examine fatigue assessment tools, its relationship with disease parameters, and treatment options, including exercise.

Main Methods:

  • Searched Medline, Embase, Pascal, and Cochrane databases.
  • Utilized keywords: fatigue, spondyloarthropathy, ankylosing spondylitis, evaluation, assessment, outcome, exercise, rehabilitation.
  • Reviewed 21 relevant papers.

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Main Results:

  • Fatigue is frequently reported in AS patients and correlates with disease activity (e.g., BASDAI) and other symptoms like pain and stiffness.
  • Sleep disturbances negatively affect fatigue levels, significantly reducing patients' quality of life.
  • Anti-TNF therapy appears more effective than NSAIDs in reducing fatigue; regular physical activity is recommended.

Conclusions:

  • No comprehensive multidimensional tool currently exists for assessing fatigue in AS.
  • Anti-TNF therapies and regular physical activity are key components for AS rehabilitation and fatigue management.
  • Exercise can alleviate fatigue and enhance the quality of life for individuals with ankylosing spondylitis.