Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interleukin-15 increases hepatic regenerative activity.

Ayako Suzuki1, Shannon McCall, Steve S Choi

  • 1Division of Gastroenterology and Department of Medicine, Duke University Medical Center, Durham, NC, USA.

Journal of Hepatology
|June 20, 2006
PubMed
Summary

Interleukin-15 (IL-15) is present in healthy livers and increases with injury. IL-15 treatment promotes liver regeneration in mice, suggesting a role in hepatic repair.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The mechanics of liver regeneration.

Science (New York, N.Y.)·2026
Same author

Disrupted Mitochondrial Copper Homeostasis Promotes Ferroptotic Stress, Senescence and MASLD Progression.

bioRxiv : the preprint server for biology·2026
Same author

The metabolic vulnerability index predicts outcomes in patients with metabolic dysfunction associated steatotic liver disease.

Nature communications·2026
Same author

A unimolecular GLP-1 and FGF21 dual agonist for treatment of metabolic dysfunction-associated steatohepatitis.

Communications medicine·2026
Same author

Vitamin E dosing study (VEDS) in patients with metabolic dysfunction-associated steatotic liver disease with elevated aminotransferases: A multicenter, randomized, placebo-controlled trial.

Hepatology (Baltimore, Md.)·2026
Same author

Hepatocyte hedgehog signaling controls ferroptosis to alleviate aging-related organ dysfunction.

JCI insight·2026

Area of Science:

  • Hepatology
  • Immunology
  • Cell Biology

Background:

  • Interleukin-15 (IL-15) plays roles in various organs, generally promoting cell survival and growth.
  • The specific functions of IL-15 in liver physiology and pathology remain largely uncharacterized.

Purpose of the Study:

  • To investigate the influence of IL-15 on hepatic integrity.
  • To determine the impact of IL-15 on liver regenerative processes.

Main Methods:

  • Assessed IL-15 and receptor expression in liver injury models, primary hepatocytes, and liver cell lines.
  • Evaluated IL-15 effects on hepatocyte viability, proliferation, and apoptosis in vitro.
  • Administered IL-15 to healthy mice to assess in vivo hepatic responses.

Main Results:

Related Experiment Videos

  • IL-15 and its receptors are constitutively expressed in healthy livers, with induced expression during injury.
  • In vivo IL-15 administration upregulated oval cell accumulation and hepatocyte replication in mice.
  • Observed focal hepatic inflammation and increased TNF-alpha and IFN-gamma, without significant cell death or aminotransferase elevation.

Conclusions:

  • IL-15 expression is upregulated in response to liver injury.
  • IL-15 administration mimics a wound healing response in healthy adult mouse livers.
  • IL-15 may play a significant role in promoting liver regeneration following damage.