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Updated: Aug 7, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
Human papillomavirus-16 in oral squamous cell carcinoma: clinical correlates and 5-year survival
Masaru Sugiyama1, Ujjal Kumar Bhawal, Makoto Kawamura
1Department of Oral Health Research, School for Oral Health Science, Hiroshima University Faculty of Dentistry, Japan. masaru@hiroshima-u.ac.jp
Abstract:
We examined 66 oral squamous cell carcinomas (OSCCs) for human papillomavirus-16 (HPV-16) infection to evaluate its prognostic significance. Cox regression analysis of 5-year survival demonstrated that patients without nodal metastasis or with intratumoural HPV-16 showed better prognoses compared with each counterpart. In Kaplan-Meier survival analysis, nodal status but not HPV-16 status was statistically significant. The 5-year survival rate of HPV-16 positive patients without nodal metastasis (94%) was extremely high, compared with that of HPV-16 negative patients with nodal metastasis (25%). These results suggest that HPV-16 status as well as nodal status may provide prognostic significance in patients with OSCC.
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