Romping the cellular landscape: linear scaffolds for molecular recognition

Multivalent molecules with a precise array of recognition elements that interact with specific cell types are important for characterizing the topology of molecules on a cell surface. Applications ranging from the control of cellular signaling to drug delivery and tissue imaging rely on these surface-mapping molecules. Linear polymers provide a molecular scaffold that is advantageous for these types of applications and their synthesis can be amenable to the introduction of different recognition elements. Recently, advances have been made in the development of synthetic approaches for preparing linear polymeric substrates with highly controlled lengths and recognition element spacing.