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Updated: Aug 7, 2026
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A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis
Published on: May 22, 2018
Identification of small-molecule inhibitors of the Abeta-ABAD interaction
Yuli Xie1, Shixian Deng, Zhenzhang Chen
1Department of Medicine, Columbia University, New York, NY 10032, USA.
Bioorganic & Medicinal Chemistry Letters
|June 20, 2006
Abstract:
The interaction of amyloid beta peptide (Abeta) and Abeta-binding alcohol dehydrogenase (ABAD) was recently implicated in the pathogenesis of Alzheimer's disease (AD). Using an ELISA-based screening assay, we identified frentizole, an FDA-approved immunosuppressive drug, as a novel inhibitor of the Abeta-ABAD interaction. Analysis of the frentizole structure-activity relationship led to identification of a novel benzothiazole urea with a 30-fold improvement in potency.
