Controlled release from a nanocarrier entrapped within a microcarrier

Area of Science:

• Colloid and Surface Chemistry
• Materials Science
• Nanotechnology

Background:

• Controlled release systems are crucial for drug delivery and material protection.
• Double emulsion systems offer potential for encapsulating nanoscale carriers within microscale vehicles.
• Fluorescein sodium salt (FSS) is a model dye molecule for studying release kinetics.

Purpose of the Study:

• To investigate the entrapment and release of fluorescein sodium salt (FSS) using a novel double carrier system.
• To introduce and evaluate the
• double carrier
• concept for simultaneous nanoscale and microscale delivery.
• To assess the potential benefits of this system for storage, handling, and application.

Main Methods:

• Encapsulation of FSS within hydrogel nanoparticles.
• Confinement of hydrogel nanoparticles within water-in-oil-in-water double emulsion globules.
• Stimulated release of FSS using hydrochloric acid (HCl) as a competing agent.

Main Results:

• Successful entrapment of FSS within hydrogel nanoparticles.
• Effective confinement of these nanoparticles within the double emulsion structure.
• Demonstrated release of FSS triggered by the addition of HCl, indicating controlled release capability.

Conclusions:

• The developed double carrier system effectively encapsulates and protects FSS.
• This system leverages both nanoscale and microscale carriers for enhanced delivery.
• The approach shows promise for improved storage, handling, and application of active substances.