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Bioengineering Human Microvascular Networks in Immunodeficient Mice
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Blood vessels engineered from human cells

Zhaodi Gong1, Laura E Niklason

  • 1Department of Anesthesia, Duke University, Durham, NC 27708, USA.

Trends in Cardiovascular Medicine
|June 20, 2006
PubMed

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The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...