Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Membrane deformation by protein coats.

Bruno Antonny1

  • 1CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, Université de Nice Sophia-Antipolis, 06560 Valbonne, France. antonny@ipmc.cnrs.fr

Current Opinion in Cell Biology
|June 20, 2006
PubMed
Summary

Protein coats drive vesicle formation by deforming lipid membranes using specialized protein structures and cellular membrane properties. These self-organized machines coordinate membrane curvature and fission for cellular transport.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: The endothelial plasma membrane lipidome and its remodeling under hyperglycemia: an exploratory study.

Frontiers in molecular biosciences·2026
Same author

The endothelial plasma membrane lipidome and its remodeling under hyperglycemia: an exploratory study.

Frontiers in molecular biosciences·2026
Same author

Effect of type-2 diabetes on surface lipids and biophysical properties in lipoprotein populations.

Archives of biochemistry and biophysics·2026
Same author

Creatine kinase B regulates glycolysis and de novo lipogenesis pathways to control lipid accumulation during adipogenesis.

Cell reports·2025
Same author

Elaboration and profiling of the first OSBP degrader issued from natural Schweinfurthins.

Bioorganic chemistry·2025
Same author

Potentiation of macrophage Piezo1 by atherogenic 7-ketocholesterol.

Cell reports·2025

Area of Science:

  • Biochemistry
  • Cell Biology
  • Membrane Biophysics

Background:

  • Protein coats are essential for vesicle formation, a fundamental process in cellular transport.
  • Vesicle budding and fission involve intricate membrane deformation and remodeling.
  • Understanding protein coat mechanisms is key to deciphering cellular organization.

Purpose of the Study:

  • To elucidate the molecular mechanisms by which protein coats induce membrane curvature.
  • To explore how protein coats utilize cellular membrane properties for efficient vesicle formation.
  • To describe protein coats as self-organized molecular machines coordinating membrane remodeling.

Main Methods:

  • Analysis of protein structures (amphipathic helices, concave surfaces).
  • Investigation of lipid-protein interactions within cellular membranes (ER, cis-Golgi, plasma membrane).

Related Experiment Videos

  • Examination of regulatory factors like protein scaffolds, curvature sensors, and GTP hydrolysis.

    • Main Results:

    • Protein coats employ amphipathic helices and concave surfaces to bend lipid bilayers.
    • Loose lipid packing and anionic lipids in specific membrane regions facilitate coat-induced curvature.
    • Protein scaffolds and GTP hydrolysis enable spatiotemporal control of coat function.

    Conclusions:

    • Protein coats are self-organized machines that leverage intrinsic membrane properties and protein tools for vesicle formation.
    • The functioning of protein coats is integrated with cytoskeletal dynamics and broader membrane remodeling events.
    • This study provides insights into the biophysical principles governing membrane shaping by protein assemblies.