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Updated: Aug 7, 2026
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A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Melanoma versus dysplastic naevi: microtopographic skin study with noninvasive method
Vittorio Mazzarello1, Daniela Soggiu, Daniela Rita Masia
1Department of Plastic Surgery, University of Sassari, San Pietro, Sassari, Italy.
Summary
Skin surface analysis using scanning electron microscopy (SEM) can help differentiate malignant melanoma (MM) from atypical nevi. This method reveals significant differences in skin texture, aiding early MM diagnosis.
Area of Science:
- Dermatology
- Oncology
- Medical Imaging
Background:
- Malignant melanoma (MM) prognosis depends on tumor thickness.
- Current ABCDE criteria for MM diagnosis are often insufficient for differentiating from atypical nevi.
Purpose of the Study:
- To investigate differences between MM and atypical nevi using skin surface analysis.
- To assess the utility of scanning electron microscopy (SEM) in MM diagnosis.
Main Methods:
- Analyzed skin surfaces of 15 MM and 15 atypical nevi using SEM.
- Employed silicone replica technique with polyvinylsiloxane for surface texture analysis.
- Included superficial spreading melanoma (SSM) and nodular melanoma (NMM) cases.
Main Results:
- MM surfaces exhibited significant irregularity.
- Cutaneous furrows were reduced or absent in MM.
- New, variably directed lines were observed on MM surfaces.
Conclusions:
- Skin surface analysis via SEM aids in diagnosing early-stage MM.
- This method assists in differentiating MM from atypical nevi.
