Pancreatic dose dependent effect of intraduodenal HCl in the anesthetized rabbit

1. A dose-response relationship between intraduodenal perfusion of different HCl loads (1.8, 4.5, 9, 18 and 45 mmol/hr) and volume, bicarbonate and protein outputs, from the exocrine pancreas of anaesthetized rabbits was observed. 2. This study also shows a dose-response relationship between the different HCl loads and the porta levels of secretin and VIP. 3. The secretin response showed a marked decrease during the stimulation period and this may suggest the involvement of a neural mechanism. 4. The plasma VIP responses were of a magnitude that might suggest a hormone role for VIP in this effect.