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Published on: January 7, 2019
Cyclin D1 splice variant and risk for non-Hodgkin lymphoma
Sophia S Wang1, Wendy Cozen, Richard K Severson
1Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, EPS MSC# 7234, Bethesda, Rockville, MD 20892-7234, USA. wangso@mail.nih.gov
Abstract:
To investigate the role of cell cycle gene variations in lymphomagenesis, we evaluated associations (odds ratios [OR] and 95% confidence intervals [CI]) in polymorphisms from seven candidate genes in 1,172 non-Hodgkin lymphoma (NHL) cases and 982 population-based controls. The cyclin D1 (CCND1) splice variant G870A (rs603965) increased NHL risk (OR(AA) = 1.4, 95% CI = 1.1-1.8, P-trend = 0.021), which was consistent for four B-cell subtypes. As CCND1 expression indicates poor NHL prognosis, our results, if true, would support its potentially dual importance in NHL etiology and survival.
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M-Cdk Drives Transition Into Mitosis
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...

