Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Quantitative trait loci for body size components in mice.

Jane P Kenney-Hunt1, Ty T Vaughn, L Susan Pletscher

  • 1Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA. jpkenney@artsci.wustl.edu

Mammalian Genome : Official Journal of the International Mammalian Genome Society
|June 20, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peripheral rotavirus-specific T-cell responses following monovalent oral rotavirus vaccine in infants.

NPJ vaccines·2026
Same author

Distribution of serotypes, biotype, and antibiotic sensitivity of Haemophilus influenzae in nasopharyngeal carrier children in Lima, Peru.

Revista peruana de medicina experimental y salud publica·2026
Same author

Genomic features of pneumococcal strains isolated from paediatric patients with invasive disease during pneumococcal conjugate vaccine introduction in Lima, Peru.

Microbial genomics·2026
Same author

Easier said than done: unexpected hurdles to preparing ∼1,000 cranial CT scans for data collection from an online digital repository.

PeerJ·2025
Same author

Secretory Immunoglobulin A Against Type-III Secretion System Proteins of Pseudomonas aeruginosa in Human Colostrum.

The Pediatric infectious disease journal·2025
Same author

Bacterial load comparison of enteroaggregative Escherichia coli (EAEC) by real-time PCR (qPCR) between children with diarrhea and asymptomatic infection.

Enfermedades infecciosas y microbiologia clinica (English ed.)·2025

Genetic architecture varies for body size components. Organ weights and long bone lengths generally have separate genetic modules, with few shared loci influencing overall body size.

Area of Science:

  • Genetics
  • Developmental Biology
  • Quantitative Trait Analysis

Background:

  • Body size is a complex trait influenced by various components like organ weights and bone lengths.
  • Understanding the genetic basis of these components is crucial for comprehending overall growth and development.

Purpose of the Study:

  • To investigate whether different body size components (organ weights, long bone lengths) exhibit distinct genetic architectures and pleiotropic patterns.
  • To identify quantitative trait loci (QTL) associated with these traits in a murine model.

Main Methods:

  • Utilized the LG/J x SM/J mouse intercross population.
  • Analyzed quantitative trait loci (QTL) for necropsy weight, four long bone lengths, and four organ weights.
  • Examined differences in QTL number, dominance, and pleiotropic patterns across trait categories.

Related Experiment Videos

Main Results:

  • Identified 97 QTLs: 52 for long bones, 30 for organ weights, and 15 for necropsy weight.
  • Long bone QTLs were generally more significant than organ QTLs.
  • Organ weights showed higher frequencies of over- or underdominance compared to long bones and necropsy weight.
  • Found 35 pleiotropic loci, with long bones often affected in groups and organs singly or in pairs.
  • Identified 11 loci affecting both organ and bone traits, 8 of which also affected necropsy weight.

Conclusions:

  • Suggests largely separate genetic modules control organ weights and long bone lengths.
  • A few loci appear to influence overall body size by affecting multiple components.
  • Antagonistic pleiotropy is uncommon among the studied body size traits.