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Related Experiment Videos

Dog colonoscopy model for predicting human colon absorption.

Steven C Sutton1, Loreen A Evans, Jay H Fortner

  • 1BioPharmaceutics Group, Pharmaceutical R&D Department, Pfizer Global R&D, Groton, Connecticut 06357, USA. steven.c.sutton@pfizer.com

Pharmaceutical Research
|June 20, 2006
PubMed
Summary
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A novel dog colon model effectively predicts human colon permeability for drug candidates. This model is valuable for drug development, excluding Class 1 compounds which show high absorption.

Area of Science:

  • Pharmacology
  • Drug Delivery
  • Animal Models

Background:

  • Predicting drug absorption in the human colon is crucial for effective drug development.
  • Existing models for colon permeability assessment can be invasive or limited in scope.

Purpose of the Study:

  • To develop and validate a canine colon model for predicting human colon permeability.
  • To assess the utility of this model across different drug physicochemical properties.

Main Methods:

  • Administered various drug compounds (BCS Classes 1-4) to the canine colon via flexible endoscopy.
  • Determined the relative bioavailability of each compound compared to oral administration.

Main Results:

  • Canine colon bioavailability correlated with drug solubility and permeability, except for small hydrophilic molecules like atenolol.

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  • The model demonstrated good prediction for BCS Classes 2, 3, and 4 drugs.

    • Conclusions:

    • The developed dog colon model serves as a reliable surrogate for human intubation studies for specific drug classes.
    • Class 1 (high solubility/high permeability) drugs are likely well-absorbed and may not require this model for assessment.