fMRI models of dendritic and astrocytic networks

In order to elucidate the relationships between hierarchical structures within the neocortical neuropil and the information carried by an ensemble of neurons encompassing a single voxel, it is essential to predict through volume conductor modeling LFPs representing average extracellular potentials, which are expressed in terms of interstitial potentials of individual cells in networks of gap-junctionally connected astrocytes and synaptically connected neurons. These relationships have been provided and can then be used to investigate how the underlying neuronal population activity can be inferred from the measurement of the BOLD signal through electrovascular coupling mechanisms across the blood-brain barrier. The importance of both synaptic and extrasynaptic transmission as the basis of electrophysiological indices triggering vascular responses between dendritic and astrocytic networks, and sequential configurations of firing patterns in composite neural networks is emphasized. The purpose of this review is to show how fMRI data may be used to draw conclusions about the information transmitted by individual neurons in populations generating the BOLD signal.