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Updated: Aug 7, 2026

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
Published on: June 14, 2019
[HPV-infection in esophageal cancer as possible predictive factor after neoadjuvant therapy]
Bognár Gábor1, Andreas Imdahl, Ledniczky György
1Semmelweis Egyetem Budapest, II. sz. Sebészeti Klinika.
Background:
Human papilloma virus (HPV) infection in oesophageal cancer cases was found 0-67% depending on different methods and geographical variances. Complete pathological response was in 30% of cases after neoadjuvant chemo-radiation (CRX). The aim of this study was to discover a possible relation between HPV-infection and response.
Material And Methods:
DNA was extracted from 26 oesophageal cancer patients undergoing CRX and surgery. PCR and Southern Blot hybridisation was used to detect HPV-infection (HPV-16 and -18). Clinicopathological parameters and disease-free survival and overall survival was also analysed.
Results:
Complete response (26.9%) and partial response (38.5%) after CRX was correlated significantly with better prognosis. 6 patient had HPV-infection (3 from CR- and 3 from PR-group).
Conclusions:
There was a correlation between HPV-infection and response, but further analysis is necessary. Both responder-groups had significantly better prognosis than non-responders.
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