Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Olanzapine: a 5-year perspective.

Kimberly H Littrell1, Richard G Petty, Nicole M Wolf

  • 1The Promedica Research Center 4460 Atlanta Highway Suite B Loganville, GA 30052, USA. khlittrell@aol.com

Expert Review of Neurotherapeutics
|June 21, 2006
PubMed
Summary

Olanzapine is a key antipsychotic for schizophrenia and bipolar disorder. Its complex pharmacology supports its use in various conditions, with future treatments possibly tailored to individual genetics.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Study of molecular targets influencing homocysteine and cholesterol metabolism in growing rats by manipulation of dietary selenium and methionine concentrations.

The British journal of nutrition·2010
Same author

Selenium and diabetes: an enigma?

Free radical research·2009
Same author

Impact of selenite and selenate on differentially expressed genes in rat liver examined by microarray analysis.

Bioscience reports·2009
Same author

Redox regulation of protein tyrosine phosphatase 1B by manipulation of dietary selenium affects the triglyceride concentration in rat liver.

The Journal of nutrition·2008
Same author

Improvement in social cognition in patients with schizophrenia associated with treatment with olanzapine.

Schizophrenia research·2004
Same author

Valproate for hostility in schizophrenia patients.

The Journal of clinical psychiatry·2004

Area of Science:

  • Pharmacology
  • Neuroscience
  • Psychiatry

Background:

  • Olanzapine is an approved antipsychotic for schizophrenia and bipolar I disorder.
  • Despite concerns about adverse events like weight gain and diabetes, olanzapine remains a vital medication.
  • Its selective monoaminergic antagonism and high-affinity receptor binding are central to its therapeutic effects.

Purpose of the Study:

  • To explore the multifaceted pharmacology of olanzapine.
  • To review the potential therapeutic applications of olanzapine beyond its primary indications.
  • To discuss the future of personalized antipsychotic treatment strategies.

Main Methods:

  • Review of existing literature on olanzapine's pharmacological profile.
  • Analysis of studies investigating olanzapine's efficacy in diverse psychiatric conditions.
  • Exploration of receptor binding affinities and their clinical implications.

Main Results:

  • Olanzapine exhibits complex pharmacology with high-affinity binding to multiple receptors implicated in psychosis and mood disorders.
  • Studies suggest potential benefits in substance abuse, aggression, personality disorders, and as a neuroprotective agent.
  • Understanding olanzapine's mechanisms may guide future treatment approaches.

Conclusions:

  • Olanzapine's broad receptor interactions contribute to its efficacy in schizophrenia and bipolar disorder.
  • Further research into its complex pharmacology may unlock new therapeutic avenues.
  • Personalized medicine, matching genetic makeup to receptor profiles, is the future of antipsychotic treatment.

Related Experiment Videos