Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Can urinary thyroid hormone loss cause hypothyroidism?

V Fonseca1, M Thomas, A Katrak

  • 1Royal Free Hospital, London, UK.

Lancet (London, England)
|August 24, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CD36 and lipid metabolism in the evolution of atherosclerosis.

British medical bulletin·2018
Same author

The PPARalpha ligand fenofibrate: meeting multiple targets in diabetic nephropathy.

Kidney international·2006
Same author

Renovascular disease is associated with low producer genotypes of the anti-inflammatory cytokine interleukin-10.

Tissue antigens·2004
Same author

Regulation of lipoprotein trafficking in the kidney: role of inflammatory mediators and transcription factors.

Biochemical Society transactions·2004
Same author

Dialysis induces cyclosporine a resistance: induction therapy with bolus ATG-Fresenius increases cyclosporine sensistivity.

Transplantation proceedings·2003
Same author

Dysregulation of LDL receptor under the influence of inflammatory cytokines: a new pathway for foam cell formation.

Kidney international·2001
Same journal

Assisted dying and the silencing of medicine's next generation.

Lancet (London, England)·2026
Same journal

Linguistic pragmatism: a woman with progressive abdominal pain in Thailand.

Lancet (London, England)·2026
Same journal

Medical compartmentalisation: a patient with chromosome 22q11.2 deletion syndrome in Japan.

Lancet (London, England)·2026
Same journal

[<sup>177</sup>Lu]Lu-edotreotide versus everolimus for gastroenteropancreatic neuroendocrine tumours (COMPETE): a phase 3, multicentre, randomised, open-label, superiority trial.

Lancet (London, England)·2026
Same journal

Research priorities for characterising Bundibugyo virus.

Lancet (London, England)·2026
Same journal

Rethinking treatment sequence in advanced gastroenteropancreatic neuroendocrine tumours.

Lancet (London, England)·2026
See all related articles

Nephrotic syndrome can be linked to hypothyroidism, with thyroid hormone levels affected by proteinuria. Urinary thyroxine (T4) excretion indicates lower thyroid hormone levels in patients with nephrotic syndrome.

Area of Science:

  • Nephrology
  • Endocrinology
  • Internal Medicine

Background:

  • Nephrotic syndrome is a kidney disorder characterized by heavy protein loss in urine.
  • Hypothyroidism, a condition of underactive thyroid, can sometimes be associated with nephrotic syndrome.
  • The relationship between thyroid function and nephrotic syndrome, particularly concerning thyroid hormone levels and urinary excretion, requires further investigation.

Purpose of the Study:

  • To investigate the association between nephrotic syndrome and hypothyroidism.
  • To assess thyroid hormone levels and urinary thyroxine (T4) excretion in patients with nephrotic syndrome and proteinuria.

Main Methods:

  • Clinical case review of four patients with nephrotic syndrome and hypothyroidism.
  • Measurement of urinary thyroxine (T4) excretion in ten additional patients with proteinuria.

Related Experiment Videos

  • Comparison of serum free T4 and free triiodothyronine concentrations between patients with and without detectable urinary T4.

    • Main Results:

    • Four patients presented with nephrotic syndrome and hypothyroidism, without thyroid antibodies.
    • Hypothyroidism resolved in two patients upon remission of nephrotic syndrome.
    • Urinary T4 was detectable in five of ten patients with proteinuria, who also had significantly lower serum free T4 and free triiodothyronine levels compared to those without detectable urinary T4.

    Conclusions:

    • Nephrotic syndrome may be associated with hypothyroidism, potentially impacting thyroid hormone levels.
    • The presence of proteinuria in nephrotic syndrome correlates with altered thyroid hormone status and increased urinary T4 excretion.
    • Further research is warranted to elucidate the mechanisms underlying the relationship between nephrotic syndrome, hypothyroidism, and thyroid hormone dynamics.