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Updated: Aug 7, 2026

Platelet-Derived Extracellular Vesicle Functionalization of Ti Implants
Published on: August 5, 2021
[Experimental study of fast formation of biomimetic apatite coatings on pure titanium surface]
Fu-ming He1, Song Chen, Li Liu
1Department of Prosthodontics, The Affiliated Stomatologic Hospital, College of Medical Sciences, Zhejiang University, Hangzhou 310006, China.
Objective:
To investigate calcium-phosphate coating on commercial pure titanium substrate using a fast biomimetic procedure.
Methods:
The titanium specimens were divided into two groups, group A and group B. The specimens of group A were only treated with the mixture of H2SO4/HCl for 30 min. The specimens of group B were treated with the mixture of H2SO4/HCl for 30 min, immersed into 5 mol/L NaOH solution at 60 degrees C for 24 h, and then heated to 600 degrees C and maintained for 1 h. All specimens were soaked into simulated body fluid-A (SBF) and SBF-B for each day. The surface morphology was observed by field scanning electron microscopy.
Results:
Dense calcium-phosphate coating deposited on all the titanium surfaces of two groups. The calcium-phosphate coating consisted of spheric structure with a diameter of 1 approximately 3 microm, which was proved to be hydroxycarbonate apatite with the analysis of X-ray diffraction.
Conclusions:
Thin hydroxycarbonate apatite coating can deposited on pure titanium using a fast biomimetic procedure.

