No association of vacuolar protein sorting 26 polymorphisms with Alzheimer's disease
M Riemenschneider1, A Schoepfer-Wendels, P Friedrich
1Laboratory of Neurochemistry and Neurogenetics, Department of Psychiatry and Psychotherapy, TU-Munich, 81675 Munich, Germany. m.riemenschneider@lrz.tu-muenchen.de <m.riemenschneider@lrz.tu-muenchen.de>
Abstract:
Using a case-control sample we evaluated a possible involvement of the Vacuolar protein sorting 26 (VPS26) gene in the pathogenesis of AD. VPS26 located at 10q22.1 denotes a retromer subunit functionally involved in the cellular trafficking of Memapsin 2 (BACE). Genotyping of eight single nucleotide polymorphisms covering the complete VPS26 gene and haplotypic analysis revealed no association with AD. Thus, we conclude that VPS26 can be excluded as a major positional and functional candidate gene conferring risk to AD.
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